Queen카지노 게임 컬렉션�s Professor Stephen Archer's technology has multiple treatment applications

By blocking an errant enzyme, Drpitor1a could fight cancer, Alzheimer카지노 게임 컬렉션�s, and pulmonary hypertension.

researchers have gained recognition for the discoveries they have made in medicine, engineering, and the sciences; innovations that have improved the lives of people around the world. To make sure that the university and the public continue to benefit from this work, Queen카지노 게임 컬렉션�s Partnerships and Innovation (QPI) promotes the discoveries of university researchers who have assigned their intellectual property to Queen카지노 게임 컬렉션�s and whose work is ready for licensing and commercial application. QPI leads the commercialization processes, including the protection of the intellectual property, the creation of strategies to further its development, the search for funders, partners, and licensees, the negotiation of terms, the management of relationships, the collection of licensing and royalty revenues, and their disbursement to inventors.

카지노 게임 컬렉션�This stuff works."

The 카지노 게임 컬렉션�stuff카지노 게임 컬렉션� that Professor Stephen Archer refers to is a compound that he and his colleagues, Dr. Danchen Wu and Dr. Michael Wells, have developed called Drpitor1a. An enzyme inhibitor, early research suggests that it may be very effective in fighting Alzheimer카지노 게임 컬렉션�s disease, pulmonary hypertension, and breast and other cancers. The challenge for Archer and Queen카지노 게임 컬렉션�s Partnerships and Innovation (QPI) is to find a partner with the skills or the financial means to take it to the next level.

Mitochondria are called the power plants of our cells, the producer of the energy that our bodies need. That카지노 게임 컬렉션�s not their only function, however. Mitochondria are typically found in a network, but this network can break down in a process called fission. Through fission they regulate cell replication, remove unnecessary or dysfunctional cell components, and participate in the removal of damaged or unwanted cells (a process called apoptosis). They do this primarily through an enzyme known as dynamin-related protein 1 (DRP-1).

In certain diseases, the production and action of DRP-1 is increased, with varying effects. In what are known as hyperproliferative diseases, such as cancer or pulmonary hypertension, the production of DRP-1 leads to greatly increased cell growth. For example, in pulmonary embolism, the blood vessels in the lungs begin to close because of proliferating cells, forcing the heart to pump harder and harder. Paradoxically, in some neuro-degenerative diseases, such as Alzheimer카지노 게임 컬렉션�s, where mitochondrial fission is increased thanks to DRP-1, it leads to cell death, not proliferation. Controlling the action of DRP-1 would help fight these diseases.

The story begins back in 2017, when Dr. Wells, in his role to commercialize intellectual property developed by Queen카지노 게임 컬렉션�s researchers, was working with the late Dr. Victor Snieckus at Queen카지노 게임 컬렉션�s. 카지노 게임 컬렉션�He had a library of synthetic compounds that we were trying to sell to industry,카지노 게임 컬렉션� says Dr. Wells, who was screening these 4,000+ compounds to see which ones might interact with biological targets. 카지노 게임 컬렉션�I was doing this for this for a lot of different researchers. I did this for Dr. Archer, and I thought there might be something there.카지노 게임 컬렉션�

카지노 게임 컬렉션�We did a lot of screening,카지노 게임 컬렉션� confirms Dr. Archer, trying to discover which of these compounds managed to block the operations of DRP-1 on the cells. 카지노 게임 컬렉션�And we found that one, Drpitor 1, worked.카지노 게임 컬렉션�

From this they have been able to develop Drpitor1a, which their U.S. patent describes as a 카지노 게임 컬렉션�novel, specific카지노 게임 컬렉션� DRP-1 inhibitor. Fifty times more potent than Mdivi-1, previously the best DRP-1 inhibitor available, Drpitor1a has proven effective and safe in the treatment of rodent models of lung cancer, ventricular damage, and pulmonary hypertension. Another independent research group has verified its effectiveness in cancer treatment. These days, as well as working on his own additional research, Archer responds to requests from researchers around the world who have heard about what he카지노 게임 컬렉션�s done and want samples to see if what he and his co-inventors have developed really is effective. 카지노 게임 컬렉션�We give it away, and we find it does what we say it does, which is really encouraging.카지노 게임 컬렉션�

For all its promise, however, Drpitor1a is still in its early stages. A Partnerships Development Officer with the QPI team, Dr. Wells says, 카지노 게임 컬렉션�part of my job is to try to sell IP developed at Queen카지노 게임 컬렉션�s to biopharmaceutical companies or license it to companies that have the financial wherewithal and the technical expertise to develop it as an actual product.카지노 게임 컬렉션� With Drpitor1a, there are currently a couple of obstacles to this. For one, the test on rats and mice aside, it is still at the pre-clinical stage. More work will have to be done. For another, the patent they hold, says Wells, covers method, not composition of matter, which 카지노 게임 컬렉션�is really important in the biochemical industry because that compound is literally your actual product.카지노 게임 컬렉션� It is not unheard-of for a company to bring a product to market based on a method patent, but it is significantly more challenging.

These obstacles, and the generally risk-averse nature of the industry aside (카지노 게임 컬렉션�the biggest lesson that we카지노 게임 컬렉션�ve learned,카지노 게임 컬렉션� says Dr. Archer, 카지노 게임 컬렉션�is that drug companies look at things very differently than academics카지노 게임 컬렉션�), there is already interest in Drpitor1a, particularly in the field of Alzheimer카지노 게임 컬렉션�s treatment.

카지노 게임 컬렉션�Alzheimer카지노 게임 컬렉션�s Research UK were interested, but they needed to get two commercial partners to commercialize our research and they could only get one.카지노 게임 컬렉션� Through QPI, says Dr. Archer, they are also talking to a couple of companies who might be interested in pursuing Drpitor1a카지노 게임 컬렉션�s development as a treatment for Alzheimer카지노 게임 컬렉션�s. As Archer points out, it doesn카지노 게임 컬렉션�t have to be an Alzheimer카지노 게임 컬렉션�s drug. 카지노 게임 컬렉션�I am kind of agnostic about this,카지노 게임 컬렉션� he says. 카지노 게임 컬렉션�It카지노 게임 컬렉션�s a drug that blocks an enzyme and whenever an enzyme카지노 게임 컬렉션�s turned on inappropriately, the drug might be beneficial.카지노 게임 컬렉션�

Going forward, Dr. Wells says, 카지노 게임 컬렉션�We could apply for grants and use that to hire a synthetic chemist and it becomes a standard drug discovery program.카지노 게임 컬렉션� One requiring a large amount of money and expertise, the kind usually found in a biopharmaceutical company. Another possibility is partnering with a company such as adMARE BioInnovations, which he says, has 카지노 게임 컬렉션�an interesting process where, if they like a technology, they카지노 게임 컬렉션�ll work with the investigator, they카지노 게임 컬렉션�ll put money into a research program to expand the chemistry, and work with Queen카지노 게임 컬렉션�s to file the intellectual property, so they might be a really good partner in this process.카지노 게임 컬렉션� Getting Drpitor1a out there, he says, 카지노 게임 컬렉션�will be tricky, but it카지노 게임 컬렉션�s really just a question of money.카지노 게임 컬렉션�

Readers interested in licensing or learning more about the technology Dr. Archer has developed, should contact Michael Wells at michael.wells@muwangwooden.com.