Research provides insights into a health-boosting ingredient of human breastmilk
New first-of-its-kind research provides insights into an important health-boosting ingredient of human breastmilk.
A team led by , Queen's 카지노게임사이트카지노 게임 컬렉션s National Scholar in Bioinformatics, partnered on the groundbreaking research in (CHILD). The major, multi-year collaboration connected breastmilk researchers at the 카지노게임사이트 of California San Diego and the 카지노게임사이트 of Manitoba with bioinformatics and computational genomics experts at Queen카지노 게임 컬렉션s 카지노게임사이트.
Published in , their research sheds light on the complex relationships among a mother카지노 게임 컬렉션s genetic makeup, the human milk oligosaccharides or HMOs (an abundant and diverse group of sugars) in her breastmilk and her baby카지노 게임 컬렉션s respiratory health.
The study카지노 게임 컬렉션s findings could inform new ways of predicting and preventing childhood disease and could facilitate new HMO-based therapies to prevent respiratory illness.
카지노 게임 컬렉션These insights may allow us to develop HMO-inspired supplements for babies and to bioengineer specific HMOs for use in research카지노 게임 컬렉션eventually perhaps even for use in therapies to treat respiratory diseases, in both children and adults,카지노 게임 컬렉션 says lead author Amirtha Ambalavanan, a postdoctoral research fellow in Biomedical & Molecular Sciences at Queen's 카지노게임사이트. 카지노 게임 컬렉션We have so much to learn from human milk."
The researchers conducted genome-wide association studies (GWASs), which simultaneously looked at millions of DNA sequence variations and how they relate to varying concentrations of 19 different HMOs found in the milk of 980 mothers participating in CHILD. They then looked at whether exposure to these differences in HMOs were associated with risk of developing recurrent wheeze, an early symptom of asthma, among the breast-fed babies. Dr. Duan카지노 게임 컬렉션s team identified strongly correlated genetic variations among the moms and the HMO composition of their milk.
카지노 게임 컬렉션My team was blown away by the significance of the GWAS signals between the maternal genomes and their HMO profiles,카지노 게임 컬렉션 says Dr. Duan, also an associate professor in the Department of Biomedical and Molecular Sciences and the School of Computing at Queen카지노 게임 컬렉션s. 카지노 게임 컬렉션Moreover, while we had expected some associated loci, our study identified a number of novel genetic associations previously not known to be involved in HMO production.카지노 게임 컬렉션
To test the strength of these findings, they conducted the same analysis in 395 mothers from another cohort, the INSPIRE Study, and found many of the same associations.
When it came to tracing the impact of HMOs on the babies카지노 게임 컬렉션 later respiratory health, the researchers found that milk with different HMO profiles appeared to affect childhood respiratory outcomes카지노 게임 컬렉션sometimes even overriding the risk carried in the children카지노 게임 컬렉션s genes. Milk with high levels of specific HMOs tends to protect babies against later developing wheeze. This impact is particularly evident among children with high genetic risk of developing asthma.
By increasing our knowledge about how HMOs are produced and how they influence health, the study points to possible new advances in healthcare and medical research.
카지노 게임 컬렉션Of course, we already know that breastfeeding provides many amazing health benefits,카지노 게임 컬렉션 comments co-author and CHILD Deputy Director Dr. Meghan Azad, a leading breastmilk researcher and Canada Research Chair based at the 카지노게임사이트 of Manitoba.
카지노 게임 컬렉션But we don카지노 게임 컬렉션t fully understand how this works at the biological level. Here we explored the complex dynamics among mothers, their milk and their babies to see how a mom카지노 게임 컬렉션s genes influence the composition of HMOs in her milk, and how these HMOs interact with her baby카지노 게임 컬렉션s genetics to influence their risk of later developing asthma.카지노 게임 컬렉션
The story was originally published by .